10 Best Calming Products For Cats 2025 in the United States

The TherapetMD Cat Calming Diffuser is a plug-in pheromone diffuser designed to reduce anxiety and stress in cats, especially in multi-cat households. It uses a natural, vet-recommended dual-pheromone formula that mimics facial and maternal cat pheromones, helping to significantly cut down behaviors like urine spraying and scratching. One of its strengths is the 700 sq ft coverage area, making it suitable for larger rooms or shared spaces.

The diffuser works continuously once plugged in, with each refill lasting about 30 days, so it’s convenient and requires minimal effort from owners. It’s fragrance-free and safe for cats, humans, and other pets, which is important for households with multiple animals or sensitive individuals. Many users report noticeable improvements in reducing hiding, fear, and tension between cats, making it helpful during stressful events like vet visits or introducing new pets. It may take a few days to see the calming effects, and the low-glow indicator light might be hard to notice in bright settings, though this doesn’t affect the diffuser’s function.

Some cats may respond differently depending on their individual preferences, so results can vary. This diffuser provides a gentle, chemical-free way to create a calmer environment for anxious or stressed cats without hassle, although patience is needed to observe the full benefits.

The Vetoquinol Zylkene Calming Supplement is designed to help small dogs and cats manage stress from situations like travel, vet visits, or loud noises. Its main calming ingredient, alpha-casozepine, comes from a milk protein, making it a natural option that avoids drowsiness or harsh side effects commonly seen in other calming products.

This supplement is lactose-free and gentle on sensitive stomachs, which is beneficial for cats with digestive sensitivities. The package contains capsules that you open and sprinkle over your pet’s food, making it straightforward to use daily. This daily routine can support behavioral issues and help your cat stay calm during stressful events.

With a solid positive rating from many users, Zylkene offers a safe, gentle, and easy-to-administer way to support your cat’s relaxation. Pet owners should monitor their cat’s response and ensure proper dosing.

The Purina Pro Plan Veterinary Supplements Calming Care Cat Supplements are well-regarded, with the brand being the number one veterinarian-recommended cat probiotic. This product uses a proprietary probiotic strain (BL999) designed to help manage stress and anxious behaviors in cats. It comes in a powder form with a liver flavor, which might appeal to many cats, making it relatively easy to administer by mixing it with their food.

The product claims to support positive behaviors, like playing and seeking social contact, while also helping to manage stress-related hormones like cortisol and support a healthy immune system. Each box contains 30 packets, enough for a month's supply, as it is recommended to give one packet daily. However, it can take up to six weeks to notice the full effects of the supplement, which might require some patience from pet owners.

Safety precautions indicate that this supplement is for cats only and should be used under the supervision of a veterinarian, particularly because the safety for pregnant cats or those intended for breeding has not been established. This could be a good option for cats that are prone to anxiety or stress, but it might not be the best fit for owners looking for more immediate results or those with pregnant cats.